As the medical industry prospers, researches on human brain have progressed significantly. Cranial cavity, formed by bones of cerebral cranium, contains the central nerve system that controls and adjusts all physiological activities of human body such as cerebrum, cerebellum and medulla oblongata. The method of measuring brain concerns the diagnosis and treatment of brain diseases. This paper presented several methods of measuring brain and discussed its development by focusing on the MRI-based measurement of children’s brain so as to provide reference for future progress and advancement of the brain measuring methods.