A reverse-phase liquid chromatographic (RP-LC) meth od was developed for the assay of Prasugrel in bulk . The Chromatography was performed on Kromasil C18 column . The eluted compounds were monitored by UV detecti on at 257nm using mobile phase methanol-potassium dihy drogen orthophosphate (pH 2.2; 10mM) (70:30, v/v). The method was statistically validated for linearity, a ccuracy, precision and repeatability. The linearity of prasugrel was demonstrated in concentration range 15-75μg/mL. The limit of detection and quantitation were 10 and 50 ng/mL. The method developed was precise, accurate and spec ific for estimation of prasugrel in bulk.