Background: The present paper reports are the simple, accurate, rapid and precise RP-HPLC method for the simultaneous estimation of Perindopril erbumine and Amlodipine besylate in the bulk and in the formulated drug substance. Methodology: The analytical method of Reverse Phase Liquid chromatographic has been performed on a Kromasil C8 (4.6 mm × 250 mm, 5 μ particle size) column with the Buffer (6.8 g Potassium dihydrogen orthophosphate) and Acetonitrile in the ratio 59:41 with adjusted pH 2.6 with orthophosphoric acid as a mobile phase and column oven temperature 40°C. Mobile phase flow rate was adjusted 1.0 ml/min. and the injection volume should be 10 μl. 210 nm was used as wavelength for the detection of sample. Results: The retention time of Perindopril erbumine and Amlodipine Besylate were found to be 4.483 min. and 6.767 min respectively. The concentration range of linearity was observed from 20% to 160% of nominal concentration of Perindopril erbumine and Amlodipine Besylate correlation coefficient was 0.999 for the both drugs. The percent recovery was found within the limits of the acceptance criteria with an average recovery 99.4% for perindopril erbumine and 99.6% for Amlodipine besylate. Conclusion: The % RSD below 2.0 shows the high precision of proposed method. method can be adopted for the routine analysis of simultaneous estimation of Perindopril erbumine and Amlodipine Besylate in pharmaceutical solid dosage.