Two validated chromatographic methods for simultaneous determination of Closantel (CLS) and Ivermectin (IVR) in veterinary drug products have been proposed. The first method was a simple HPTLC method where separation was performed on HPTLC silica gel 60 F254 plates using toluene: isopropanol: ammonia 33%: glacial acetic acid (70:28:10:1, by volume) as a developing system, Rf values were found to be 0.35 and 0.65 for CLS and IVR, respectively. The second method was an isocratic HPLC method where separation was performed on a C18 column using acetonitrile: methanol: 5mM ammonium dihydrogen phosphate buffer PH 6 (60:30:10, by volume) as a mobile phase. Retention times were found to be 1.2 min and 2.6 min, respectively. The linear ranges of the first method were found to be 0.2-12 µg band-1 and 0.06-3 µg band-1; those of the second method were found to be 0.5 -500 µg mL-1 and 0.5-200 µg mL-1 for CLS and IVR, respectively. Both methods were validated according to the ICH guidelines and applied for the determination of the two drugs in drug substance and drug products without interference from reported excipients.