A specific and accurate HPLC method is developed for the determination of Alfuzosin inbulk drugs and in solid tablet dosage form. Best symmetric peak shape obtained with Symmetry C18, 150x4.6 mm, 5 μm column in an isocratic mode, with retention time 15 min.The mobile phase used was buffer, acetonitrile and tetrahydrofuran in the ratio of 810:180:10 v/v/v with flow rate 1.5 ml/min and wavelength monitored at 245 nm. As per ICH guidelines method has validated. Method has found linear in the range of 25-75 μg/ml. Method was found specific with respective of diluents, excipients and degradants.