The main objective of the present study was to develop a polyherbal solid dosage formulation and to evaluate antiinflammatory activity with specific COX-2 inhibitory activity. Based on the available traditional and scientific literature, plants that possess anti-inflammatory activity were selected. The extracts were prepared by successive soxhlation using solvents like petroleum ether, chloroform, ethyl acetate, methanol and water. In vitro evaluation of the extracts was done by HRBC membrane stabilisation method using diclofenac sodium as standard to study the anti-inflammatory activity. In vitroCOX-2 inhibitory activity of the same extracts was evaluated by enzyme immunoassay method. Herbal tablets were prepared by direct compression method by using the fractions with potential COX-2 inhibitory activity obtained by fractionation of the active extracts by column chromatography. Five tablet formulations with varying concentration of the active fractions of various herbs were prepared and standardised. All the formulations were further studied for specific COX-2 inhibitory activity among which, Polyherbal formulation IV proved to show pronounced invitro COX-2 inhibitory activity.