A simple and rapid reversed phase high performance liquid chromatography (RP-HPLC) method has been developed for simultaneous determination of metoprolol tartrate (MET) and hydrochlorothiazide (HTZ) in tablet dosage form. The chromatography was carried out on a C 18 (250 mm x 4.6 mm, 10 μm) column. The components were separated isocratically with a mobile phase consisting of 35 volumes 0.5 % v/v orthophosphoric acid, 15 volumes of methanol and 50 volumes of acetonitrile at a flow rate of 1.0 ml/min. The UV detector was set at 280 nm. The retention times for MET and HTZ were found to be 3.19 min and 8.37 min, respectively. The method was validated for the parameters like specificity, linearity, precision, accuracy, limit of quantitation and limit of detection. The method was found to be specific as no other peaks of impurities and excipients were observed. The square of correlation coefficients (R2) for MET and HTZ were 0.9999 and 0.9985 while percentage mean recoveries were 99.76 % and 99.56 %, respectively. Intra- and inter-day relative standard deviations for both the components were <2.0%. The proposed RP-LC method can be applied for the routine analysis of commercially available formulations of these drugs either as such or in combination.