In present study, we deigned a series of N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides derivatives based on reported pharmacophore as HIV-integrase enzyme inhibitor and synthesized by reaction of 2-oxo-2h-chromene-3 carbonyl chloride with derivative of amino thiadiazole. The structures of these compounds were confirmed by IR, NMR and Mass spectroscopy. Further insilico pharmacokinetic studies of these compounds were carried out by using Schrodinger and Pallas software. Insilico ADME studies of these compounds demonstrate that all compounds show drug-likeliness or follow the Lipinski rule of 5 so that all compound are orally active, No one compound gives violation of drug likeliness. One the basis of ADME studies, we concluded that all compounds can be used for second generation of development.