Several effective anticancer therapeutic drugs containing coumarin nucleus targeting carbonic anhydrase enzyme. Thus, some coumarin derivatives 1-22 were prepared. The structures of these compounds established on the basis of IR, 1HNMR, 13CNMR and MS data. Moreover, the optimization geometries for compounds 1-22 were discussed using DFT theory with B3LYP\6-311G base set. The molecular docking simulations into the active site of COX-2 were performed, and showed that, some compounds (7,8, 11,13,19b and 20) suitable inhibitor against CAII, and can used as anti-cancer drugs. These compounds (7,8, 11,13,19b and 20) were evaluated against Ehrlich solid carcinoma (EAC) tumor model in Swiss albino mice on dose 50μg . The activity was assessed using survival time and average increase in body weight, which showed that, administration of derivatives (7,8, 11,13,19b and 20) were effective in reducing solid tumor mass EAC cells. In silico, The ADMET profiles showed that, these compounds are good oral bioavalability, and the most active compounds 6 and 10 are CNS active agents without marked health effects observed for rodent