In the present study, Adapalene gels were prepared using CMC Na, HPMC, HPC, Carbomer and combinations of cellulose derivatives; as base and PluronicPE-6200 as penetration enhancer for the treatment of Acne. The gels were evaluated for drug content, viscosity determination, in vitro permeation (Nylone-66) and stability studies. The d rug content of the gels was found to range from 98-105.7 %. The viscosity of the gels ranged b etween 7100-83144 cps. . In-vitro diffusion profile of Adapalene gel (optimized formula F-22) o btained in ethanol with water (80:20) indicate that 40.33% drug release found within 6 hr s. while 35.22% of marketed preparation. Although the difference is insignificant, the perce ntage release of drug was found to increase in the following order of the polymer composition: Car bopol-980> Carbopol-940> Carbopol-934> HPC > SODIUM CMC> HPC+SODIUM CMC > METHYL CELLULOSE > HPMC > HPC+HPMC. Further the formulation F-22 was found to be stable at accelerated stability condition with respect to percent drug content, rel ease characteristics, pH, transparency, feel and viscosity.