Infertility is a widespread health problem worldwide and the level of serum inhibin B is one of the main factors affects infertility in males. Alternatively, exposure to lead element has shown the strong induction of infertility. In the present study, for the first time we evaluated the effects of curcumin, a herbal compound which recently attracted much attention in herbal medicine, on the level of inhibin B expression in lead pre-exposed mice. Furthermore, we were seeking to determine if there is any relationship between the level of inhibin B and the presence of lead and how curcumin may exert synergistic effect. According to our data, curcumin remarkably decreased the negative effects of lead in lead-treated mice and reduced the expression of inhibin B. Here, we showed the effect of curcumin on testes of lead-treated mice and evaluated how it neutralizes oxidative stress in mice caused by exposure to lead. Curcumin is a strong candidate and is able to be used as a therapeutic compound in treatment of infertility.