Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 2

Conseption and evaluation of Gemfibrozil as immediate drug delivery system

Abstract

Immediate release tablets are widely used for its better therapeutic availability, in this present work a pharmaceutically equivalent, low cost quality improved formulation of Gemfibrozil as Immediate release tablets were developed Gemfibrozil is a 5-(2,5 – dimethyl phenoxy) – 2,2- dimethyl pentanoic acid which is a fibric acid derivative used in the treatment of Hyperlipidaemic by using micro crystalline cellulose, pregelatinized starch, sodium starch glycollate and calcium stearate as excipient. According to Biopharmaceutical Classification System Gemfibrozil is classified under class-II drugs(low solubility-high permeability) and it was compared with the innovator and effect of LOD on Gemfibrozil immediate release tablets were studied and to evaluated the formulations for the physical parameters such as uniformity of weight, disintegration time, friability, moisture content, thickness, hardness and drug content and the best formulations were coated with opadry white and comparative invitro dissolution profile of the coated formulation with that of the innovator product had shown that F6 formulation best matched with innovator and the formulations are loaded for the stability studies.

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