The aim of this study was to compare the psychological hardiness and lifestyle of patients with coronary heart disease and healthy people from 40 to 65 years old in Isfahan city.The research method was causal – comparative and the research population included all patients with coronary heart disease in Isfahan Cardiovascular Research Center in 2015 and non-patient companions. A simple random sampling method was used for coronary heart disease (93 patients) and available for healthy subjects (83 person).The data collection tool were Ahwaz's Psychological Hardiness Questionnaire (Kaymarthi et al., 1998) and lifestyle Questionnaire (LSQ) of Lali et al. (2012) [2]which was performed for both groups. The findings showed that there is a significant difference between psychological hardiness (P= 0.001) and lifestyle (physical health, exercise, weight control, disease prevention, mental health, spiritual health, social health, drug avoidance, accident prevention and environmental health (P= 0.001) between the two groups of patients with coronary heart disease and normal. Based on the findings of the research can be considered psychological hardiness and healthy life styles as a constitutive and proactive factor for coronary heart disease