Bisorption of lead by using red betle (Piper crocatum) and and green betle (Piper betle) leaves had been studied through batch method. The effect of pH, initial concentration, bisorbent dosage and contact time were investigated to find the best condition in order to achieve the optimum biosorption capacity. Isotherm Langmuir and Isotherm Freundlich model were used to check conformity of adsorption process. Morphological change and functional groups that involve during the biosorption process were observed by Scanning Electron Microscope and Fourier Transform Infra Red Spectrosopy, respectively. Batch studies indicate that the optimum biosorption capacity was achieved at pH 4, initial concentration 1,800 mg/L and adsorbent dosage 0.1 g for both biosorbents. Whereas contact time achieved optimum value at 120 minutes and 15 minutes for Piper crocatum and Piper betle leaves, respectively. SEM’s images showed that significant difference before and after Pb(II) ion uptake binding into the surface of biosorbent. FTIR analysis indicated functional group of OH stretching, C=O carbonyl that play a role in adsorption due to wavelength shifted. Both of these biosorbents fit to isotherm Langmuir model based on the value of R2 0.9576 and 0.9959 for Piper crocatum leaf and Piper betle leaf. Piper crocatum leaf give the best adsorption process to remove Pb(II) ion from aqueous solution with removal percentage 92.65 %.