Mental depression is a major disorder of mood prevalent in a large percentage of the population and it disrupts the normal social life. The need of effective and well tolerated antidepressants has prompted to examine herbal plants that have been traditionally used for depression. Both Vetiveria zizanioides and Foeniculum vulgare are the common source of the well known oil, particularly used in aromatherapy and regarded as a tonic to the nervous system. Research showed the relationship between inflammation and depression and it is proved that both plants possess significant anti-inflammatory effect .So our aim is to compare the effects of the antidepressant drug fluoxetine and the combination of Vetiveria zizanioides and Foeniculum vulgare on depressive behavior in albino rats. Both Forced swimming test(FST) and Tail suspension test(TST) were used for screening antidepressant effect, The ethanolic extract of Vetiveria zizanioides(100mg/kg) and Foeniculum vulgare (200mg/kg) together, fluoxetine(10mg/kg) and saline were administered 30mts prior to the tests and the immobility period was recorded for 6mts.The antidepressant effect of both were compared to that of fluoxetine. Vetiveria zizanioides(100mg/kg) and Foeniculum vulgare (200mg/kg) produced significant antidepressant effect by reduction in immobility period as compared to control. But as a group together they are equally effective as fluoxetine (10mg/kg) The results of the present study indicated the antidepressant activity of Vetiveria zizanioides and Foeniculum vulgare and their potential for use of an adjuvant in depression.