In present study, an attempt has been made to evaluate a Comparative study of powder v/s gel of proniosomal drug delivery system of flurbiprofen. Flurbiprofen, are nonsteroidal anti-inflammatory drug (NSAIDs) is used for the relief of pain and inflammation associated with rheumatoid arthritis and osteoarthritis. It exhibits antiinflammatory, analgesic and antipyretic activities. It will be also effected the transdermal system rate because of its size, nature and chemistry, these systems give better drug permeability from biological bioavailability membranes and helps in solubilization of some practically insoluble drugs and hence solve problems of many drug. In the present study we are using various surfactants like span 20, 40, 60, 80, and brij 35 and studided in various proniosomal powder and gel formulation and studied in both result in following formulation. In this result proniosomal gel of formulation brij 35 show better entrapment and highest in vitro drug release. The best result obtain in which formulation which having equimolar ratio(1:1) of brij 35 and cholesterol.The release mechanism was explained with zero order, first order, higuchi equations. Thus it can be concluded that the proniosomes gel posses higher entrapment efficiency and utilizes alcohol, which itself act as penetration enhancer. The elicited an increase of the percutaneous permeation of flurbiprofen both in-vitro and in-vivo. In addition, in vivo experiments showed that flurbiprofen proniosomes gel can ensure a sustained release of the drug and hence a prolongation of its therapeutic activity, which can be related to an accumulation of flurbiprofen in the skin.