Aim of the study was to assess the efficacy of analgesic coated suture material for post-operative pain relief.A total of 20 patients who reported to the Department of Periodontology in whom flap surgery was recommended after clinical evaluation and phase I therapy were included in the study. The subjects were divided into 2 groups by simple randomization using lottery method, with 10 patients in each group i.e., Group A (Test-analgesic coated sutures and placebo tablets), Group B (Control-conventional sutures and oral analgesics). Following surgery pain parameters were assessed after 30 minutes, after 1 day and after 1 week using VAS scale and a respondent sheet.On intergroup comparison, statistically significant difference was noted in VAS score wherein Group A demonstrated better results when compared to Group B.Analgesic coated suture material was found to be better in improving pain parameters after periodontal flap surgery.