The purpose of this research was to evaluate the effectiveness of several types of chemical compound insecticide combined with food bait to Iridomyrmex cordatus population as the agent of pod rot disease, Phytophthora palmivora, in the cocoa plant. The research is expected to find out better insecticide trial in pressing ant population. This research was conducted in Muktisari region (North Luwu district). Research design consisted of 5 trials (5 replications per trial) and to analyze data, regression analysis was used. Ant populations were measured based on scoring referred to Way and Khoo (1989) method; score 1= less than 50 population, score 2= 50 – 200 population, score 3= 200 – 500 population and score 4= more than 500 population observed. The average of ant population reached the highest score in the treatment of Fenvalerate with score 3.0 (about 350 population), meanwhile the lowest score was in the treatment of Chlorpyrifos reaching score 2.1 (about 200 population). All trials seemed to reduce population of I. cordatus. However, a noticeable reduction of ant population was shown in Chlorpyrifos trial (A2) and Carbaryl (A4).