Based on the structure of jet-swirl nozzle, a new nozzle called multi-inlet jet-swirl nozzle (MIJSN) was designed for preparing nano-drug by SEDS process. The innovative character of the new nozzle is three same swirl vane distributed uniformly in the circumferential of swirl insert and used to introduce same solvent. MIJSN was validated by computational fluid dynamics (CFD) simulation. Volume fraction of methylene chloride and turbulent intensity were selected to act as indicators in order to compare MIJSN with jet-swirl nozzle. Results indicate that MIJSN can obtain more uniform mixing in the swirl chamber than jet-swirl nozzle and can be utilized to prepare nano-drug with sharper particle size distribution. The three swirl vanes uniformly distributed in the circumferential of MIJSN contributed a lot to the even mixing