RFID technology in logistics system is widely used as the core in Internet of things and plays an important role in the field of logistics management. The EPC code is stored in the RFID tag, can realize the identification of the real target. Cloud computing is a distributed processing, parallel processing and grid computing development, distributed in a large number of distributed computers through the calculation, rather than the local computer or a remote server, enterprise data center operation will be more similar as internet. The paper presents build intelligent logistics system based on Internet of things RFID in the platform of cloud computing. Simulation results validate the effectiveness of the proposed model.