In pharmaceutical science various transmucosal routes are here but buccal route is suitable for local and systemic drug delivery. Buccal route is approachable route for therapeutic agent and avoid the enzymatic degradation and first pass metabolism that will lead the higher bioavailability. Current review include the advantages, disadvantages, buccal mucosa: overview, mechanism action of drug, ideal properties for permeation of drug, factors affecting bioavailability, mucoadhesive polymers, classification of various mucoadhesive polymers, theory of bioadhesion, evaluation of buccoadhesive dosage form and conclusion.