The aim of this study was to analyze the scientific production that has been produced about biological activities of Xylopia frutescens. This is an integrative review conducted in databases: Latin American and Caribbean Center on Health Sciences Information; Medical Literature Analysis and Retrieval System Online; Scopus and virtual libraries Scientific Electronic Library Online, SciFinder Scholar and PubMed. The papers were analyzed with variables as title of articles, authors, country, journal, database, year of publication, language, approach, and study type, parts of studied plant species, results and conclusion of articles. It were found 75 articles and after analysis were selected 11 articles, 8 (72.7%) articles in Scopus database, 3 (27.3%) in Scifinder, other periodic presented repeated articles and others were not found. The articles were published from 1982 to 2016. The studies were conducted in Brazil (72.7%), Germany (9.1%), French Guiana (9.1%) and France (9.1%). The parts of the plant species used were leaves, fruits, stem bark, stem and seeds. The activities evidenced in the articles were antimicrobial, antifungal, antiinflammatory, antitumor, trypanocidal, spasmolytic and antiplasmódico. Hence, it is concluded that plant species in question presented in the articles analyzed a wide biological activity, providing significant information for designing new studies with Xylopia frutescens.