This paper describes the antioedematogenic, analgesic and antimicrobiologic profile of a methanolic extract of Marrubium vulgare. The results of evaluation of the anti- inflammatory activities against inflammation induced by carrageenen and PGE-2, and analgesic activity in the p-benzoquinone-induced abdominal constriction test showed that the activity of the methanolic extract at a 200 mg/Kg dose was similar to that of the reference drugs. The extract also showed a significant anti-microbial activity at 200, 400, and 600 mg/mL. Our results support the use of M. vulgare in traditional medicine in Mediterranean region for its anti-inflammatory, analgesic and anti-microbiologic properties