The toxic effects of sodium arsenite, As (III) and its amelioration with Moringa leaf powder @ 0.1% and ascorbic acid @ 200 ppm in broiler chicken was investigated. In the present study, chicks of day-old age belonging to Vencobb strain were assigned to six groups (I,II,III,IV,V,VI) consisting of eighteen chicks in each group. Group I served as control (basal diet) and birds in group II were given sodium arsenite @ 200 ppm in basal diet for 42 days. Group III and IV were given Moringaoliefera leaf powder and ascorbic acid @ 0.1% and 200 ppm in basal diet respectively. Group V was fed, diet containing sodium arsenite @ 200 ppm and Moringa leaf powder @ 0.1% for 42 days. Birds in group VI were given with sodium arsenite @ 200 ppm and ascorbic acid @ 200 ppm in basal diet for 6 weeks. Six birds from each group were sacrificed at fortnightly intervals. Blood, serum and tissue samples were collected.Over all mean values of Hb,PCV and TEC levels in control groups were in normal range whereas levels were significantly (P<0.05) decreased in toxin group. The serum biochemical assays showed significant (P<0.05) reduction in total protein, albumin, globulin, while significant (P<0.05) increase in AST, GGT was observed in group II birds. Oxidative stress parameters revealed significant (P<0.05) decrease of liver GSH in group II. The ameliorative groups V and VI showed marked improvement in all the above parameters as compared to toxic group. Grossly group II birds revealed enlarged liver with hyperemia and extensive haemorrhages and histopathological lesions in group II comprised of severe sinusoidal and venous congestion with mononuclear cell infiltration. In conclusion, sodium arsenite caused a significant toxicity in broiler chicken and its amelioration with Moringa oleifera leaf powder and ascorbic acid was effective in combating the arsenic induced toxicity