In this paper, the design of wireless sensor node is serial communication module with IEEE/ZigBee transmission module to replace the traditional, logistics collected data will be wirelessly sent. The GRPS communication circuit is mainly composed of a power supply circuit, GPRS module, SIM interface circuit and the serial interface circuit part. Its core is the GPRS module. The paper presents application of ZigBee wireless sensor network and GPRS in development of intelligent logistics system. Intelligent logistics system can solve the real-time information acquisition and logistics operation by ITS and related information technology, and carries on the collection of information in an integrated environment analysis and processing.