The reasonable design of ground motion has a critical influence on the aseismic design of building structures. Given the importance of high-rise buildings, site survey data are generally in great detail. The design of ground motion, including the response spectrum design and seismic wave design, is one of the important parameters for aseismic design of building structures. In this case, The paper makes full use of the data and reasonably designs response spectra and seismic design in intelligent buildings which are more appropriate to the characteristics of specific sites of high-rise buildings than determining seismic input based on a simplified method and limited data.