This paper describes an optimization method for rapid determination of cadmium in sea water by adsorptive stripping voltammetry using response surface method. The influence of several parameters were studied : variations of calcon concentration, pH, accumulation potential and accumulation time. The design study was a central composite design with 4 factors / variables 3 levels and 31 treatment combinations. From the results of experiments and statistical evaluation (the results of analysis of variance) it was decided to accept the second-order model and the independent variable concluded that a significant effect on the response variable (peak current). Based on data analysis with response surface method, the determination of cadmium obtained optimum conditions are: concentration of calcon 0.47 mM, pH = 7.47, -0.59 Volt accumulation potential and accumulation time of 70.36 seconds with a maximum peak current value of cadmium 11.07 nA. At the optimumum condition were obtained relative standard deviation of 0.41%, 98.91% recovery, the linear range up to 105 μg/L with a detection limit of 0.12 μg/L. The response surface method can be applied to the determination of cadmium in sea water rapid, effectively and efficiently.