Talinum paniculatum (Portulacaceae) is popularly kn own in the region of Patos de Minas, Minas Gerais State, Brazil, as “Maria Gorda” or “Benção-de-Deus” and in traditional medicine it is used to treat inflammatory processes in general. After dried and fragmented, the plant was sequentially submitted to exhaustive percolation with hexane, ethyl acetate a nd methanol. The crude extracts were investigated f or their anti-edematogenic and anti-nociceptive activi ties through formalin-induced paw edema model. In comparison with a non-steroidal anti-inflammatory d rug (NSAID) indomethacin, the hexane and ethyl acetate extracts showed higher anti-edematogenic an d anti-nociceptive activity. In addition, through phytochemical studies, from these extracts were iso lated and identified potassium nitrate ( 1 ), the mixture of long chain hiodrocarbons hentriacontane ( 2 ), dotriacontane ( 3 ), tritriacontane ( 4 ) and pentatriacontane ( 5 ). heneicosanoic acid ( 6 ), the ester nonacosyl nonacosanoate ( 7 ), urea ( 8 ), 3-O- β -D- glucosyl- β -sitosterol ( 9 ); the mixture of β -sitosterol ( 10 ) and stigmasterol ( 11 ), and a pentaciclyc triterpene 3-O-acethyl-aleuritolic acid ( 12 ). X-Ray difratometry was used for the characteriza tion of inorganic constituent. TLC, HR-CG and spectrometric methods (IR. 1 H and 13 C NMR) were used to identify the structures of organic compounds. To th e best of our knowledge, it is the first time that compound 1 to 8 and 12 are cited as constituents of T. paniculatum.