The aim of the present study was to examine the possible protective achieve of diosmin against Cadmium (Cd) induced renal toxicity. Male Wistar albino rats were divided into four groups of six animals each. Group II animals administered intraperitoneal (i.p) with CdCl2 (2 mg/kg body weight/day) dissolved in saline for 10 days to tempt oxidative stress, alterations in urinary enzymes, lipid profile, and ATPase of nephrons in rats. Administration of CdCl2 significantly induced renal toxicity which was evident from the increased levels of urinary constituents and altered biochemical enzymes. Cadmium Chloride stimulated kidney damaged rats were administrated with diosmin counteracts biochemical alterations were recovered. The swiftness of recuperation was more rapidly when diosmin (40 mg/kg body weight dissolved in saline once daily through oral administration for 28 days) was administered for management after the exposure of animals to cadmium. These findings suggest that diosmin may attenuate Cd induced renal toxicity and source for treatment of Cd mediated environmental disorder.