This study aims to evaluate the anti micro filarial activity of the extract of C. aerugenosa rhizome (Zingiberaceae). Rhizomes of Curcuma aerugenosa were collected from the community garden in Langsa, Aceh, Indonesia. A total of 50 g C. aerugenosa flour were weighed and dissolved in 10 ml of distilled water, stirred with a spatula until mixed, then filtered. A total of 2 ml of Curcuma rhizome extract given to Rabbit with different concentration i.e. 5%, 10%, 15%, 20%, 25% and observed every 24 hours. The highest percentage of microfilaria decrease after 24 hours was found in P6 (27.54%) followed by P4 (22.22%), P5 (20,24%), P3 (18,67%), P2 (17,28) %) and P1 (12.82%). The percentage of microfilarial reduction by an extract of C. aerugenosa rhizome was 49.28% after 72 hours of treatment. Statistical analysis showed that there was a significant effect of all treatment on the decrease of microfilariae amount (P <0,05). Extract of C. aerugenosa rhizome has an anti-microfilarial effect with the best concentration found at 25% concentration.