Some novel resins which have ion exchange properties and anti-microbial activities were synthesized by polycondensation reaction of substituted resorcinol, furfural and biuret using hydroxybenzoic acid as catalyst. The structures of these resins were conformed using various characterization techniques such as FTIR, H1-NMR spectral data. The antibacterial screening against Escherichia coli, Proteus vulgaris, Bacillus substillis, staphylococcus and antifungal activity against Drechera halodes, Fusarium oxysporium of the resins were evaluated. It is found that Parachlorophenyl substituted based copolymer resin is more active than other resins.