The dried extract of plant Aristolochia indica is used as anti-inflammatory , anti-pyretic and analgesic activity against the venom extract of H.fossilis which present in the glandular cell (Poison gland) present in base of pectoral spine. The LD50 of a H.fossilis extract in oral and IV doses were about 40 mg/kg/day and 29mg/kg/day respectively. The volume of inflammation caused by venom extract was seen upto 10 µl/ml safely. The viability of the 10mg/kg conc. of plant extract in 10 rats under test with conc. of venom 5 µl/ml to 100 µl/ml showed that extention of rats survival upto the concentration of 30 µl/ml and the inflammation at that point was 0.20 ml which was too less than 0.84 ml of control study with venom only. The calibration of inflammatory effect from 1 µl/ml to 10 µl/ml was extracted maximum at conc. of 4µl/ml v/v which gave an average inflammation of 0.84ml on 10 rats. The combined administration of the extract of plant and venom shows the more resistivity of venom in rats proving the extention of the conc. of venom effectiveness from 4µl/ml to 7µl/ml v/v and also the volume of inflammation gets retarded upto the range of 0.01 ml to 0.21 ml .