Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint swelling, joint tenderness, and destruction of synovial joints, leading to severe disability and premature mortality. Acacia catechu Willd. Commonly known as karungali in Tamil and Khadira in Sanskrit .Chemical constituents are well known for their potential health benefits and have been reported to possess valuable biological activities such as antibacterial and antifungal, antioxidant, antiurolithiatic, anticonvulsant and anxiolytic, and hepato protective properties. The aim of this article is to investigate the Anti inflammatory activity of Acacia catechu Bark ethanolic extract.