The crude extract of polychaete Namalycastis fauveli was screened for its Antifungal activities. Extracts were obtained from the whole body tissues of the animals to test against different pathogenic bacteria (Escherichia coli, Staphylococcus aureus and Salmonella typhi). The crude extracts were also fractionated and elutions were made with methanol. Eluted fractions were assayed for Antifungal activity followed the disc diffusion method. In polychaete Namalycastis fauveli fraction I (66%), the zone of inhibition against Staphylococcus aureus is significantly (P<0.05) recorded. In case of Bacillus substilus, it is significantly (P<0.05) observed in fraction I, V, and VI (31%) and III (21%), IV (12%) and fraction VII (7.81%). The zone of inhibition of E.coli is significant (P<0.05) observed in fraction VII (27%).