The different solvent extracts of Raphanus Sativus L. leaves (Family: Brassicaceae) were tested for antidiabetic activity using alloxan induced diabetic rats and compared with standard. The results expressed that aqueous extracts had shown significant protection and maximum reduction in blood glucose was observed in alloxan induced diabetic rats (p<0.001). The results of this comprehensive study reveal that R. sativus L leaves showed statistically significant Antidiabetic activity in comparison to the standard glibenclamide.