Lung cancer is a malignant tumor that characterized by uncontrolled cell growth in tissues of the lung. It is the most common cancer type causes death. The present study aimed to find and identify anticancer compound against lung cancer from the flower of Lantana camara plant. The wild L. camara was collected from the desert of 6th October city, Egypt. The yellow flowers were dried and extracted by different solvents with increasing polarity. The anticancer activity of each extract was investigated against lung carcinoma cell line by MTT test. The hexane extract that showed anticancer activity was purified by silica gel column eluted with ethyl acetate and methanol. The ethyl acetate fraction that showed the anticancer activity against lung cancer cells was analyzed by GC/MS. The analysis showed presence of 24 compounds including aliphatic and oxygenated hydrocarbons and mono and sesquiterpenes (sabinene, cis-Ocimene, Eucalyptol, Geranyl isovalerate, Menthol-1'-(butyn-3-one-1-yl), 7-epi-trans-sesquisabinene Hydrate, trans-Caryophyllene, tau.-Cadinol and Limonen-6-ol-pivalate. Several previous investigations reported presence of most of these terpenes in the essential oils that showed anticancer activities against different types of cancer cells. So, the present study is an addition for the anticancer activities of essential oils. Through this study we strongly recommend evaluation of such essential oils in in-vivo experiments against different types of cancer cells, as an initial step for clinical trials and chemotherapy of cancer disease.