Marine peptides have inherent activity, largely unexplored and ability to revolute against challenges. Molluscans, one of major group of invertebrates are not only of highly delicious seafood because of their nutritive value but also they are very good source for bio-medically important active compounds. Many bioactive compounds from gastropods, cephalopods and bivalves exhibiting antitumor, anti-leukemic, anti-bacterial and anti-viral activities have been reported worldwide. The anti-bacterial activities of tentacle, ink and shell extracts of cephalopod- Loligo duvauceli was studied. The anti-bacterial assay was done against Escherichia coli and their zones of inhibition were studied after plating and incubation. The results have led us to continue further research for isolation and purification of the compounds responsible for their activity.