Antimicrobial resistance remains global public health problems. Several pathogenic diseases were found to resist a number of drugs e.g. S. serotypes, S. pneumonia, Enterococcus spp, S. typhimurium, and S. pyogenes among others. However many other strains of bacterial pathogens were found to develop resistivity against more than one antibiotics, hence this phenomenon is refer to as multidrug resistance. Thus approaches to recover the present condition are needed. This study was aimed to assess antibacterial effect of different part of Moringa oleifera Lam. The results showed that bark and combination of stem with bark extracts had inhibitory effect against all gram positive bacteria studied. And the most susceptible bacteria was found to be S. aureus (ATTC 33591) while the most resistant one was P. aerogenosa (ATTC 12453). Hence it proves the claimed that many part of Moringa oleifera contains phytochemicals compounds capable of acting as either bacteriostatic or bactericidal activity.