This study was aimed to investigate the antibacterial and antioxidant activity of the methanolic extract of Strychnos nux vomica flowers. Results showed that the plant was able to inhibit all the microorganisms chosen however its effect was higher with Candida albicans and Klebsiella pneumoniae with Chloramphenicol (10ug/ml) as the standard drug of choice. The samples were evaluated for their radical scavenging activity against the synthetic DPPH(2,2-diphenyl-1-picryl-hidrazila), results showed a high antioxidant activity. Further, this study showed that the flowers of this plant can be used to treat against infections caused by these tested microorganisms. More research is needed to isolate the active compounds, determine the structural composition and their mode of action in inhibiting these bacteria.