The plant kingdom is a treasure house of potential drugs and in the recent years there has been an increasing awareness about the importance of medicinal plants. Drugs from the plants are easily available, less expensive, safe, efficient and rarely have side effects. The Indigofera Aspalathoides commonly known as Sivanar Vembu has been recognized in different system of traditional medicines for the treatment of different ailments of human beings. In this present study the antimicrobial activity of extracts of root, stem, leaf, and at different solvents in different concentration were evaluated against some human pathogenic gram positive and gram negative bacteria. The minimal inhibitory concentration of the extracts of root, stem and leaf in different solvents were also studied. The results were tabulated and discussed in this present communication.