A large number of medicinal plants are claimed to b e useful in skin disease in all traditional system of medicine and folklore. While these plant remedies a re being used orally and by local application. Looking to the scope of herbal drug and increasing demand especially in disease of liver, cancer, diabetes, hypertension, renal disease, inflammation , infectious diseases and skin diseases etc. Plumer ia rubra Linn. has been selected because of its easy o f availability, therapeutic value and degree of res earch work which is not done. Plumeria rubra Linn. is a d eciduous tree with thick, widely distributed in common rather moist garden, in lawns and in open pl antation tree is unusual in appearance. Plant loses leaves for a short time during the winter. Slowly g rows up to height 25 feet with 35 spread. About eig ht species of Plumeria rubra (L.) occurs in India. The ascending branches leave simple Alternate, spiral, elliptic or ovate shape, base tapering (narrow atte nuate) or oblique, margins entire or undulate, apex acuminate or acute or obtuse. Pink or red color flo wers and flowering period is August to October. According to Ayurveda; root is bitter, carminative, thermogenic, etc. Leaves are useful in inflammatio n, rheumatism, antibacterial, antifungal, bronchitis, Antipyretic etc. The in vitro antibacterial activit y of ethanolic, chloroform, ethyl acetate and aqueous ex tract of leaves of Plumeria rubra (L.) has been evaluated using disc diffusion method against S. ep idermidis and Escherischia coli of bacterial strain s. Comparatively, extract showed significant antibacte rial activity with specific standard (Ciprofloxacin ).