Anti-inflammatory and wound healing activity of topical application of Curcuma aromatica Salisb. rhizome extract and is cream formulations in Arachidonic acid -induced ear inflammation and excision wound model was confirmed in albino mice. The extraction of these rhizomes was carried out by ethanol. The ethanol extract and formulations exhibited significant antiinflammatory activity in arachidonic acid - induced ear inflammation. It also showed significant wound healing activity in excision wound model. Thus, resultant anti-inflammatory activity might be due to effects on several mediators and arachidonic acid metabolism involving cyclooxygenase pathway resulting in prostaglandin synthesis.