The present study deals with the investigation of phytochemically evaluated aqueous extract of leaves of Mangifera indica L. Var. Thotapuri for its anti-inflammatory activity. The activity was evaluated by carrageenan induced rat paw edema method for acute inflammation and cotton pellet granuloma method for chronic inflammation. The standard drug used was Diclofenac sodium (10 mg/kg) for both the models. In these methods, ethyl acetate and ethanol extracts at a dose level of 300 mg/kg has shown significant activity which is comparable to that of the standard.