Original Articles: 2011 Vol: 3 Issue: 2
Analytical method development and validation protocol for Lornoxicam in tablet dosage form
Abstract
Lornoxicam (chlortenoxicam) is a non steroidal anti- inflammatory drug (NSAID) of the oxicam
class with analgesic, anti-inflammatory and antipyretic properties. It is available in oral and
parental dosage formulation. Lornoxicam is a yellow or slightly yellow powder. It is slightly
soluble in water, soluble in sodium hydroxide, slightly soluble in methanol. A simple
spectrophotometric method was developed for the determination of lornoxicam in
pharmaceutical tablet dosage form. Lornoxicam exhibiting λ max at 258 nm in mobile phase
(0.05 M NaOH) and obeyed linearity in the concentration range of 5-30mcg. The proposed
method was statistically validated.