A simple, sensitive and precise RP-HPLC method for simultaneous estimation of Amlodipine Besylate (AMB) and Atorvastatin calcium (AVC) has been developed and validated for determination of compounds in commercial tablet dosage form. The compounds were well separated isocratically on a ODS 3V inertsil column using a mobile phase consisting of buffer (pH 3.5) & Methanol (45:55) with a flow rate of 1.0 ml/min with UV Visible detector at 246nm. Retention time for Amlodipine Besylate and Atorvastatin calcium were found to be 2.19 & 3.71 respectively. The study showed that the reverse phased liquid chromatography is sensitive and selective for detecting Amlodipine Besylate and Atorvastatin calcium using the single mobile phase. The method has been validated for linearity, accuracy and precision. The mean recoveries obtained for Amlodipine Besylate & Atorvastatin calcium were found to be 100.61% and 99.23% respectively. Developed RP-HPLC method was found to be accurate, precise, selective and rapid for simultaneous estimation of Amlodipine Besylate & Atorvastatin calcium in tablets.