This paper made an experimental study on the attenuation law of basic mechanical properties of concrete after the action of freeze-thaw cycle, and constructed a mathematical model of complete compressive stress-strain curve equation of concrete. Based on the test data, compressive stress-strain relation of concrete after the action of freeze-thaw cycle was gained. Besides, a comparison was made between experimental value and theoretical value of compressive stress-strain relation of concrete after freeze-thaw, which verified the accuracy of the established mathematical model. By studying the attenuation law of anti-frost property and mechanical properties of concrete, its change rule was revealed. This has provided basic data for theories of frost resistance durability design for concrete structure in practical engineering.