The present work reports eco friendly synthesis of a new series of 2,4-disubstituted-1,5-benzodiazepine derivatives which is achieved by the condensation of o-phenylenediamine and various substituted chalcones under microwave irradiation. The structures of the synthesized compounds were confirmed through IR and 1H NMR spectroscopy. This method is based on the principles of ‘Green Chemistry’, rendering the method to be facile, efficient and environmentally benign. It afforded all the synthesized compounds in good to excellent yields and the reaction time was considerably short. The clean reaction conditions, easy work-up, time saving and higher yields are notable advantages of the present method.