Eight new heterocyclic moiety containing Schiff bases have been synthesized by the condensation of aromatic amines with substituted benzaldehyde under organic solvent free condition efficiently in the presence of water. The Schiff bases were obtained in good yields and were easily isolated by filtration. Their structures were confirmed by IR, 1HNMR and elemental analysis. Most of the Schiff bases have showed potent antibacterial activity.