The aim of the present study was to synthesize a series of new lignans intermediates as antimicrobial inhibition agents were synthesized by a simple procedure. The cyclocondensation reaction of (Z)-3-(ethoxycarbonyl)-4,4- (diaryl)but-3-enoic acids, 1(a-d) with acetic anhydride in glacial acetic acid produced Ethyl 4-acetoxy-1-aryl-2- naphthoates 2(a-d) and with polyphosphosphoric acid yielded ethyl 1-aryl-4-hydroxy-2-naphthoates 4(a-d) in good yields. The synthesized compounds were evaluated for their antimicrobial activity. The new compounds were characterized by IR, 1H NMR, 13C NMR, MS studies and elemental analysis. Results of antimicrobial activity reveal that some of the synthesized compounds act as potential antimicrobial agents different fungal and bacterial organisms.