Microwave assisted organic reaction enhancement (MORE) is a simple, clean, fast, efficient, economic and environment friendly method developed for the synthesis of Trazodone hydrochloride, Aripiprazole and their key process intermediates. Using microwave irradiation, all the reaction could be completed in a very short duration (≤ 2 minutes) with desired increase in the yields (>10%) and purity of the compounds. Final proposed method is repeated three times to ensure its reproducibility and robustness. All the synthesized compounds were compared with products from conventional method by studying mixed melting point, Co-TLC, NMR and IR spectra.